The Kettles and their fifteen children are about to be evicted from their rundown rustic home when Pa wins the grand prize by coming up with a new tobacco slogan. Birdie Hicks is jealous of the family's new wealth, which includes a completely automated modern home, and accuses Pa of stealing the slogan. Reporter Kim Parker proves Birdie wrong and marries Tom Kettle.
Ma and Pa, along with daughter Rosie, go off to Hawaii in answer to cousin Rodney's call for help running his pineapple farm while he recovers from an illness. Pa soon causes a major explosion and gets himself kidnapped.
When Pa wins a jingle-writing contest, he and Ma head for New York City. They they get in trouble with gangsters when they lose some stolen money which they had already agreed to deliver to one of the thugs.
The Kettles leave their ultra-modern home and return to the country looking for uranium. Ma and Tom's mother-in-law, Mrs. Parker, fight over whether their grandchild will be raised "hygiencially."
The Kettles are in Paris along with their daughter-in-law's parents the Parkers. Pa tries to buy racy postcards. He also gets in big trouble when he is given a letter to deliver to Adolph Wade, a spy who gets killed by spies Inez and Cyrus Kraft.
Ma and Pa are trying to raise enough money at the county fair to send their daughter Rosie to college. Ma competes in baking and Pa enters a trotter in a horse race, while Rosie takes up with handsome young Marvin Johnson.
The Indians try to make a fire in the Kettles fireplace the old fashion way, the smoke signal way. Judges are a comin' to award a child with a scholarship. However, who ever has the nicest looking farm and raises their kids in a good enviroment has a chance of winning.
Ma and the kids head out to help Pa's brother Sedgewick with the his farm in Mournful Hollow, Arkansas. Things get tighter when a couple of bootleggers rent Sedge's barn to manufacture moonshine. With Ma and the kids, the bootleggers get their pay.
Ma and Pa do their bit to hook lumberman Brad Johnson up with spoiled socialite Sally Flemming. Ma teaches Sally how to behave like a hick so she'll be compatible with Brad.